Skip to main content

Table 1 Anticancer activity of gefitinib as a single agent against 9 osteosarcoma cell lines

From: EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance

 

Gefitinib (IC50; ÎĽM)a

 

FCSb

Cell line

0.1 %

1 %

10 %

HL-NG

6.9

6.1

9.2

MG-63

5.1

15.3

16.3

HOS

12.1

18.2

19.9

Saos-2

13.8

21.5

27.1

OS-10

6.0

10.1

32.8

OS-9

7.3

8.5

29.5

SARG

3.6

4.1

31.2

IOR-MOS

2.8

10.4

31.5

U-2 OS

28.1

35.9

36.0

  1. aGefitinib concentrations causing a reduction of cell viability by 50 % as compared to the untreated controls
  2. bAmount of fetal calf serum (FCS) added to the respective growth media