Index | Wild type group | Tpl2 knockout group | ||
---|---|---|---|---|
Animal number (n) | 26 | 20 | ||
Final body weight (g) | 41.2 ± 3.2 | 38.1 ± 5.9* | ||
Liver weight (g) | 2.5 ± 0.8 | 2.1 ± 0.3* | ||
Liver/body weights (%) | 6.2 ± 2.4 | 5.6 ± 1.1 | ||
Incidence of liver tumor (%) | 100 % (26/26) | 75 % (15/20)* | ||
Liver tumor number/per animal | 11 ± 6 | 10 ± 5 | ||
Histopathology of hepatic lesion# | n | % | n | % |
Hyperplasia | 26 | 100 | 3 | 15* |
Hepatocellular adenoma | 26 | 100 | 12 | 60* |
Hepatocellular carcinoma | 26 | 100 | 0 | 0* |
Incidence of inflammation foci (%) | 65.4% (17/26) | 20 % (4/20)* | ||
Inflammation foci number (cm2) | 2.2 ± 2.4 | 0.6 ± 1.4* | ||
Hepatic steatosis (median) | 2 | 1* | ||
Hepatic steatosis grading | n | % | n | % |
 0 | 1 | 3.8 | 8 | 40 |
 1 | 2 | 7.7 | 4 | 20 |
 2 | 15 | 57.7 | 4 | 20 |
 3 | 8 | 30.8 | 4 | 20 |