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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma

Fig. 4

PD-L1 expression was up-regulated in hepatoma-bearing mice. a Neutrophils in mice were gated and analyzed according CD11b+Ly6G+. b Data shown was from tumour-bearing mice of PD-L1 expression on neutrophils in circulation and tissue. c Data shown was from tumour-bearing mice of PD-1 expression on CD4+ T cells and CD8+ T cells in circulation and tissue. d The percentage of PD-L1+ neutrophils was shown in tumour-bearing mice (n = 8). e PD-1 expression was increased slightly on CD4+ and CD8+ T cells in the blood and spleen of hepatoma-bearing mice vs. naïve mice (n = 8). Experiments were performed in at least three independent studies. BL, blood; SP, spleen; TT, tumour tissue. Data are presented as the mean ± SEM. *P < 0.05

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