Fig. 6
From: Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer
Effect of KPNA2 knock down on nude mice transplantation tumor of RKO cells. RKO cells with mock transfection (a) or KPNA2-shRNA1 (b) were implanted into the flanks region of four nude mice. a After tumor development, the animals were sacrificed and tumors were removed. b The HE staining of xenograft tumors from (a Mock group). c The HE staining of xenograft tumors from (b sh-KPNA2 group). d The tumors from different groups were weighted. e Expression of KPNA2 and OCT4 mRNA were detected in Mock and sh-KPNA2 groups by Real-time quantitative PCR. f KPNA2 and OCT4 protein expression in Mock and sh-KPNA2 groups were detected by western blot. KPNA2 and OCT4 expression were suppressed in sh-KPNA2 group