Fig. 2

Survival and macroscopic tumor growth following intracerebral injection. a Fluorescence image of the dorsal surface of the scull bone showing the injection site (cross) located 2 mm anterior to the coronal suture (dashed arrow) and 1 mm lateral to the sagittal suture (solid arrow). b–c Low and high magnification fluorescence images of the injection site on the dorsal surface of the brain 1 h after intracerebral injection of 10⁴ GFP-transfected A-07 cells. d Survival versus time for mice injected with A-07, D-12, R-18, and U-25 cells. e Fraction of mice with macroscopic meningeal tumor growth at autopsy. Columns and bars represent mean and SEM of three separate experiments, each involving ten mice. Survival curves in d are based on pooled data from all three experiments and include 30 mice per cell line