Fig. 4

Intertumor heterogeneity in growth and invasion at the injection site and in the ventricles. a–b Low and high magnification images of GFP-stained (a) and HE-stained (b) histological brain sections showing tumor growth at the injection site following intracerebral injection of R-18 and D-12 cells. Arrow indicates a blood vessel with co-optive tumor growth. c–d GFP-stained (c) and HE-stained (d) brain sections showing tumor growth in the lateral (c) and fourth (d) ventricles following intracerebral injection of R-18 and D-12 cells. e Survival versus time for R-18 mice with and without ventricular tumor growth (V+ and V-), and R-18 mice with and without macroscopic meningeal tumor growth (M+ and M-)