Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo

Table 1 Treatment effect of vernodalin and TAM on animal body weight (g), tumor volume (mm³) and tumor reduction percentage (%) in LA-7-induced breast cancer rats

Group	Treatment groups	Body weight (g)	Tumor volume (mm³)	Tumor reduction percentage (%)
I	NC	247.3 ± 1.5	0	0 %
II	TC	213.13 ± 1.32	2143 ± 363	0 %
III	TT (1 mg/kg vernodalin)	219.14 ± 7.2	1182 ± 352*	44.84 %
IV	TT (10 mg/kg vernodalin)	221.57 ± 5	524 ± 261*	75.6 %
V	TT (1 mg/kg TAM)	224.88 ± 5.7	562 ± 145*	73.78 %

Each value represents mean ± S.D. of given number of animals (n = 5). “*” denotes statistically significant at p < 0.05 compared to control group

ISSN: 1756-9966