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Table 3 Multivariate prognostic factor analysis for PFS and OS

From: Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data

 

HR (95 % CI)

p-value

Progression-free survival

ECOG PS, 1/2 vs. 0

1.94 (1.31-2.89)

0.001

CA19.9, ≥157 U/ml vs. <157 U/ml

1.58 (1.08-2.33)

0.019

Gender, female vs. male

1.49 (1.04-2.14)

0.028

Lung metastases, yes vs. no

1.48 (1.02-2.14)

0.040

Overall survival

ECOG PS, 1/2 vs. 0

3.56 (2.25-5.61)

<0.001

Stage, metastatic vs. locally advanced

3.25 (1.58-6.69)

0.001

CA19.9, ≥157 U/ml vs. <157 U/ml

1.96 (1.25-3.05)

0.003

  1. Abbreviations: ECOG PS Eastern Cooperative Oncology Group performance status, HR hazard ratio; 95 % CI, 95 % confidence interval