Fig. 1

Expression and correlation of MTA1 and E-cadherin transcripts in MPM patients. a Significantly higher RNA expression of MTA1 in tumor specimens than in the adjacent tissue samples (p < 0.001). b Significantly decreased RNA expression of E-cadherin in tumor specimens in comparison with adjacent tissues (p < 0.001). c A negative correlation between MTA1 and E-cadherin in tumor samples (r = −0.5482, p < 0.0001). d Immunohistochemical staining of E-cadherin in MTA1 overexpression tumor tissue (CASE 1) and MTA1 low expression tumor tissue (CASE 2) in vivo. Data are represented as mean ± SD. *p < 0.05, **p < 0.001. e and f Average value of integrated optical density (IOD) of E-cadherin in MTA1-high group and MTA1-low group were assessed by analyzing five fields per slide and recorded in the histogram. MTA1, metastasis-associated gene 1; MPM, malignant pleural mesothelioma