Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

Table 4 Relationship between CD68, CD163 expression levels of tumors and clinical variables

Variable	No.	CD68				CD163
Variable	No.	N	L	H	P	N	L	H	P
Sex					0.081				0.008
Male	74	15	19	40		35	25	14
Female	53	6	8	39		13	18	22
Age (years)					0.668				0.642
≤50	26	5	4	17		8	9	9
>50	101	16	23	62		40	34	27
Tumor location					0.324				0.405
Tongue	52	10	12	30		20	17	15
Gingiva	26	3	2	21		8	11	7
Buccal mucosa	31	3	8	20		11	9	11
Lip	4	2	1	1		4	0	0
Floor of the mouth	2	0	1	1		0	1	1
Others	12	3	3	6		5	5	2
Tumor size					0.419				0.124
T1	21	5	3	13		9	4	8
T2	68	9	14	45		23	24	21
T3	26	4	5	17		14	7	5
T4	12	3	5	4		2	8	2
Lymph node metastasis					0.044				0.098
N0	72	15	19	38		33	22	17
N (+)	55	6	8	41		15	21	19
Metastasis					0.542				0.535
M0	125	21	27	77		48	42	35
M (+)	2	0	0	2		0	1	1
Clinical stage					0.564				0.114
I	12	4	2	6		7	2	3
II	42	7	10	25		17	14	11
III	34	4	7	23		14	9	11
IV	39	6	8	25		10	18	11
Pathological grade					0.986				0.537
I	76	12	17	47		31	25	20
II	42	8	6	28		15	16	11
III	9	1	4	4		2	2	5
Recurrence					0.870				0.01
No	83	14	16	53		35	32	16
Yes	42	7	11	24		13	10	19
Lost	2	0	0	2		0	1	1
Follow-up					0.560				0
Live	91	16	17	58		41	33	17
Dead	33	5	10	18		7	9	17
Lost	3	0	0	3		0	1	2

No., number of patients; N, negative; L low expression; H, high expression. N0, no lymph node metastasis; N (+), node metastasis. M0, no metastasis; M(+), metastasis
Bold values signify P < 0.05

ISSN: 1756-9966