Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

Table 6 Relationship between E-cadherin, vimentin expression levels of the tumors invasive front and clinical variables

Variable	No.	E-cadherin				Vimentin
Variable	No.	N	L	H	P	N	L	H	P
Sex					0.554				0.024
Male	74	20	28	26		37	18	19
Female	53	15	24	14		19	8	26
Age (years)					0.988				0.209
≤50	26	7	11	8		12	8	6
>50	101	28	41	32		44	18	39
Tumor location					0.123				0.508
Tongue	52	15	21	16		26	9	17
Gingiva	26	6	6	14		12	7	7
Buccal mucosa	31	11	15	5		10	6	15
Lip	4	1	1	2		1	2	1
Floor of the mouth	2	1	1	0		2	0	0
Others	12	1	8	3		5	2	5
Tumor size					0.970				0.818
T1	21	5	8	8		10	4	7
T2	68	21	28	19		27	16	25
T3	26	6	13	7		12	4	10
T4	12	3	3	6		7	2	3
Lymph node metastasis					0.236				0.003
N0	72	23	25	24		40	15	17
N (+)	55	12	27	16		16	11	28
Metastasis					0.665				0.159
M0	125	35	51	39		56	26	43
M (+)	2	0	1	1		0	0	2
Clinical stage					0.236				0.043
I	12	3	3	6		9	2	1
II	42	17	13	12		21	8	13
III	34	5	19	10		13	6	15
IV	39	10	17	12		13	10	16
Pathological grade					0.659				0.007
I	76	20	29	27		40	16	20
II	42	13	20	9		15	10	17
III	9	2	3	4		1	0	8
Recurrence					0.460				0.01
No	83	22	32	29		43	19	21
Yes	42	12	20	10		13	6	23
Lost	2	1	0	1		0	1	1
Follow-up					0.301				0.001
Live	91	22	39	30		47	21	23
Dead	33	12	13	8		9	4	20
Lost	3	1	0	2		0	1	2

No., number of patients; N, negative; L low expression; H, high expression. N0, no nodal metastasis; N(+), nodal metastasis. M0, no metastasis; M(+), metastasis
Bold values signify P < 0.05

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