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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma

Fig. 3

sgRNA knockout of JunB in metastatic HNSCC cells suppresses tumor migration but not cell proliferation. a Western blotting analysis of KCC-T871 cells transfected with control sgRNA or JUNB sgRNA (#1 and #2). b The confirmation of genome-editing in KCC-T871 cells transfected with sgRNA-mediated JunB knockout. The efficiency of sgRNAs targeting JunB was measured using a GeneArt Genomic Cleavage Detection kit. c sgRNA knockout JunB in KCC-T871 cells inhibited cell migration. Columns, mean % of wound closure; bars, SEM. **P < 0.01 ***P < 0.001. d The cell proliferation ability of KCC-T871, KCC-T871/crControl, KCC-T871/JUNB/KO#1 and KCC-T871/JUNB/KO#2 were all similar in the cell viability assay

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