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Table 3 Top 20 lists of upstream key molecules in lung metastatic versus non-metastatic HNSCC cells

From: JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma

Key molecules

score

FOS

26

JUNB

23

FOSL1

21

PPARG

21

IRF8

20

IRF1

19

CBP

18

IRF4

18

ISGF3G

17

IKK-beta

16

FOXA2

14

IRF7

14

NR3C1

14

JUND

13

Src-isoform1

13

IRF2

12

beta-catenin

11

c-Myc-isoform1

11

MKK4beta

11

p38alpha

11

  1. Microarray data were loaded into the ExPlainâ„¢ pathway search tool and key nodes were searched in the upstream pathways. Each key node is assigned a score based on its connectivity of the pathways. Molecules with higher score could be considered as key factors regulating the pathways related with distant metastasis of HNSCC