Fig. 1

MiR-548c is downregulated in endometrial and ovarian cancer tissues and decreased miR-548c levels associates with worse prognosis in patients with endometrial cancer. Box plots showing decreased expression of miR-548c (a, b) and increased Twist (c, d) mRNA expression in 50 ECs and matched adjacent normal tissues (top), and in 60 OCs compared to 20 normal ovarian tissues (bottom), assessed by the quantitative real-time RT-PCR (qPCR) assays. Of note, downregulation of miR-548c (b) and upregulation of Twist (d) was detected in serous, advanced stage and grade 3 OC samples. Kaplan-Meier survival curves of EC (e) and OC (g) patients in The Cancer Genome Atlas (TCGA) data set were created using the SurvMicro database. In ECs, high-risk patients exhibited significantly lower levels of miR-548c compared to the low-risk patients (f). h MiR-548c expression between high-risk and low-risk OCs (TCGA). ^** P < 0.01