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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Integrated analysis of microRNA regulatory network in nasopharyngeal carcinoma with deep sequencing

Fig. 3

MiRNAs regulatory networks by IPA. a The miRNA-mRNA interaction network. miR-34 family targeted most genes and the relationship between it and 5 highlighted genes (CCND1, TP53, BCL2, MET, CDK6) was experimentally confirmed. b TP53-centered network showed TP53 could be treated as diagnostic marker of NPC and was involved in cell cycle regulation and mTOR signaling. c CCND1- centered network indicated CCND1 was involved in both p53 signaling and PI3K/AKT/mTOR signaling. d BCL2-centered network showed BCL2 acted significantly in molecular mechanisms of cancer and functioned through apotosis signaling

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