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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1

Fig. 4

Knockdown of HOXA1 expression suppresses tumorigenicity in vivo. a BGC-823-shHOXA1 and BGC-823-Control cells were injected subcutaneously into nude mice. After 3 weeks, the tumors were dissected. The tumors of mice in the BGC-823-shHOXA1 group were smaller than the tumors of BGC-823-Control group. b Tumor volume of the BGC-823-Control and BGC-823-shHOXA1 groups 3 weeks after cell injection (*P < 0.05). c Tumor weight of the BGC-823-Control and BGC-823-shHOXA1 groups 3 weeks after cell injection (**P < 0.01). d H&E- and IHC-stained paraffin-embedded sections obtained from the xenografts. IHC staining showed that the expression of Ki67 was weaker in the BGC-823-shHOXA1 group than in the BGC-823-Control group. Original magnification, 200×

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