Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1

Table 1 Expression of HOXA1 and cyclin D1 in normal mucosae, GC tissues, and lymph node metastases

Expression of HOXA1 or cyclin D1	Tissue samples			P value
Expression of HOXA1 or cyclin D1	Normal mucosae (n = 264) (%)	GC tissues (n = 264) (%)	LNM (n = 104) (%)	P value
HOXA1
Negative	203 (76.9)	120 (45.5)	30 (28.8)	<0.001^,*
Positive	61 (23.1)	144 (54.5)	74 (71.2)	0.004^,**
cyclin D1
Negative	231 (87.5)	127 (48.1)	41 (39.4)	<0.001^,***
Positive	33 (12.5)	137 (51.9)	63 (60.6)	0.132
HOXA1/cyclin D1
Both negative	170 (64.4)	89 (33.7)	24 (23.1)	<0.001^,****
One positive	94 (35.6)	69 (26.1)	23 (22.1)	0.033^,*****
Both positive	0 (0.00)	106 (40.2)	57 (54.8)

GC gastric cancer
LNM lymph node metastases
P value calculated using chi-square test or Fisher's exact test
^*Significant difference
Significant difference in the expression of HOXA1^**, cyclin D1^****, or HOXA1/cyclin D1^***** among normal mucosae, GC tissues, and LNM
Significant difference in the expression of HOXA1^*** and HOXA1/cyclin D1^****** between GC tissues and LNM

ISSN: 1756-9966