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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Fig. 5

HIF-2α promotes EMT through Twist binding to the promoter region of E-cadherin. a Twist1 and Twist2 expressions in response to up-regulation or silencing of HIF-2α in pancreatic cancer cells were detected by Western blot. b ChIP of Twist1 and Twist2 interactions with the E-cadherin promoter. Bands are PCR products targeting P1 and P2 of the E-cadherin promoter. The specific anti-Twist1, anti-Twist2 or control normal mouse IgG was used for immunoprecipitations, whereas genomic DNA was used as the input control

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