Fig. 6

Nude mice tumor formation assay and the expression of SOCS3 in the tissue microarray. a Images of xenograft tumors in nude mice formed by SOCS3 gene stably transfected Bxpc3 cells and the controls. b Tumor volume and weight of xenograft tumors in nude mice were quantitatively evaluated. c Represenative staining patterns of negative IHC staining of SOCS3 in pancreatic cancer tissue sample (T1) while moderate staining in matched pericancerous tissue (P1) in the tissue microarray. The image P2 was classified as weak staining of SOCS3 in the pericancerous tissue. d Quantification of SOCS3 IHC staining in the pancreatic cancer tissue microarray (The difference between pancreatic cancer and pericancerous tissues is significant, P = 0.005). e Kaplan-Meier survival method and log-rank test were used to evaluate overall survival and compare the differences between the two groups based on the SOCS3 status, P = 0.034