Table 1 The dynamic changes of the inflammatory cell populations in pancreatic lesions during pancreatic cancerogenesis (%, Mean ± SEM)

Inflammatory cells

15.50 ± 3.45

27.04 ± 4.75^*

30.53 ± 5.57^*

34.53 ± 5.45^*

45.23 ± 5.40^**#&

49.54 ± 6.91^**#&@

Th

15.13 ± 3.34

15.02 ± 3.47

11.02 ± 3.46

10.44 ± 2.30

8.03 ± 2.40^*#

8.67 ± 3.11^*#

2.15 ± 0.57

4.24 ± 0.94^*

3.45 ± 1.01^*

3.62 ± 0.54^*

3.75 ± 2.40^*

4.12 ± 0.93^*

CTL

12.05 ± 3.55

12.51 ± 3.74

10.12 ± 2.13

7.11 ± 3.40

7.05 ± 2.05^*#

6.04 ± 2.55^*#

1.74 ± 0.25

3.21 ± 0.78^*

3.23 ± 1.01^*

2.87 ± 0.48^*

3.3 ± 1.00^*

3.04 ± 0.68^*

B cell

15.07 ± 3.52

16.40 ± 4.22

15.28 ± 3.00

16.24 ± 3.02

14.00 ± 3.25

11.34 ± 3.26

2.12 ± 0.26

4.37 ± 1.01^*

4.55 ± 0.87^*

5.44 ± 0.75^*

6.30 ± 1.24^*

5.39 ± 1.27^*

Granulocyte

35.56 ± 7.22

37.04 ± 5.78

40.52 ± 7.53

47.55 ± 5.07^*

55.24 ± 7.30^*#

60.24 ± 8.67^**##

5.27 ± 1.26

10.51 ± 2.33^*

13.11 ± 2.46^*

15.78 ± 3.61^**

25.78 ± 3.89^**#&@

31.12 ± 4.97^**##&@

Mφ

12.22 ± 3.45

11.55 ± 3.22

14.28 ± 2.77

17.12 ± 4.54^#

20.05 ± 4.43^*#

22.15 ± 3.65^*#

1.58 ± 0.42

3.24 ± 0.60^*

3.51 ± 0.89^*

5.91 ± 1.10^**#

9.18 ± 2.16^**##&&@

12.11 ± 2.47^**##&&@

DC

7.24 ± 2.25

8.46 ± 3.70

6.74 ± 4.22

10.86 ± 3.36

12.25 ± 4.57

11.23 ± 3.45

0.97 ± 0.47

2.15 ± 0.45^*

2.04 ± 0.47^*

3.56 ± 1.01^*

5.52 ± 1.46^**#&

5.31 ± 1.89^**#&

NK

6.10 ± 1.22

5.84 ± 2.33

5.42 ± 1.65

6.24 ± 2.94

5.54 ± 1.93

4.22 ± 1.58

0.88 ± 0.24

1.68 ± 0.67^*

1.98 ± 0.49^*

2.27 ± 0.75^*

2.51 ± 0.68^*

2.29 ± 0.84^*

NKT

3.01 ± 0.55

3.12 ± 0.97

2.01 ± 0.18

2.02 ± 0.65

2.76 ± 1.15

2.84 ± 1.44

0.44 ± 0.21

0.91 ± 0.31

0.67 ± 0.12

0.75 ± 0.09

0.91 ± 0.21

0.83 ± 0.08

MDSC

5.24 ± 2.16

7.25 ± 2.55

9.25 ± 3.42^*

14.14 ± 2.75^**#

15.25 ± 3.55^{**# &}

22.34 ± 4.22^**##&&@$

0.75 ± 0.15

1.79 ± 0.27^*

2.75 ± 0.55^*

3.64 ± 0.68^**#

6.78 ± 1.45^**##&&@

10.20 ± 2.07^**##&&@@$

M1

8.54 ± 2.24

8.11 ± 2.78

7.55 ± 2.40

8.67 ± 3.70

9.44 ± 2.12

9.58 ± 2.55

1.11 ± 0.27

2.41 ± 0.43^*

2.55 ± 0.38^*

2.97 ± 0.55^*

4.27 ± 1.10^**#&

4.68 ± 1.25^**#&@

M2

2.72 ± 1.05

2.55 ± 1.17

5.01 ± 1.23^*

5.15 ± 1.87^*

6.94 ± 2.70^*#

11.22 ± 2.77^**##&@$

0.29 ± 0.05

0.65 ± 0.10^*

1.51 ± 0.42^**#

2.25 ± 0.84^**#

3.14 ± 0.42^**##&

5.87 ± 1.28^**##&&@$