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Table 4 The changes of the inflammatory cell populations in tumor tissue after chemotherapy (n = 6, %, Mean ± SEM)

From: Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages

Population

Tumor tissue

Control

Chemo.

Chemo. + ASP

Chemo. + Lip

Chemo. + ASP + LIP

Inflammatory cells

45.57 ± 6.55

41.01 ± 6.00

38.50 ± 7.43

35.50 ± 4.77

36.55 ± 6.79

Th

14.24 ± 2.54

8.10 ± 2.55*

8.24 ± 2.22*

7.12 ± 2.44*

7.44 ± 2.45*

 

6.71 ± 1.33

3.54 ± 1.55*

3.27 ± 1.25*

2.75 ± 0.87*

2.72 ± 1.01*

CTL

9.52 ± 1.05

5.57 ± 1.24*

6.22 ± 1.57*

6.11 ± 1.47*

6.22 ± 2.45*

 

4.05 ± 0.74

1.95 ± 0.57*

2.32 ± 1.05*

1.87 ± 0.48*

2.01 ± 1.14*

B cell

10.11 ± 2.54

18.27 ± 3.54*

18.71 ± 1.33*

17.70 ± 2.02*

19.07 ± 2.44*

 

4.01 ± 1.11

7.32 ± 1.76*

6.91 ± 1.05*

6.45 ± 1.02*

7.01 ± 1.27*

Granulocyte

31.13 ± 5.65

26.54 ± 4.32

27.58 ± 4.76

27.79 ± 3.33

25.50 ± 4.50

 

12.70 ± 2.95

10.11 ± 2.75

9.97 ± 2.64

9.45 ± 1.45

9.57 ± 2.27

Macrophage

17.62 ± 3.26

25.17 ± 3.22*

17.03 ± 2.55#

32.04 ± 4.77**#&

25.88 ± 3.46*&

 

7.45 ± 1.81

10.25 ± 2.02

6.52 ± 1.57#

13.14 ± 1.68*&

9.69 ± 1.78&

DC

7.17 ± 1.33

14.24 ± 2.32*

17.77 ± 2.34*

16.24 ± 1.66*

15.01 ± 1.68*

 

3.02 ± 0.56

5.87 ± 1.02*

6.75 ± 1.42*

5.64 ± 0.56*

5.42 ± 0.78*

NK

5.34 ± 1.64

4.32 ± 2.17

4.72 ± 1.02

4.44 ± 1.13

4.41 ± 1.02

 

1.34 ± 0.43

1.27 ± 0.33

1.12 ± 0.24

1.04 ± 0.35

0.97 ± 0.28

NKT

2.34 ± 1.26

3.35 ± 1.58

2.55 ± 0.88

2.24 ± 0.15

4.02 ± 1.21

 

0.82 ± 0.45

1.05 ± 0.37

0.96 ± 0.46

0.81 ± 0.17

1.11 ± 0.48

MDSC

19.76 ± 4.31

11.65 ± 3.25*

6.34 ± 1.11**#

11.57 ± 1.89* &

7.50 ± 1.45**#@

 

9.05 ± 2.37

4.75 ± 1.64*

2.88 ± 0.74**#

4.28 ± 0.58*&

2.70 ± 0.84**#@

M1

9.34 ± 2.76

10.22 ± 2.66

10.23 ± 2.67

10.23 ± 3.12

9.37 ± 2.45

 

3.72 ± 1.43

4.11 ± 1.23

3.56 ± 1.26

3.45 ± 1.24

3.03 ± 1.05

M2

11.98 ± 3.26

18.22 ± 3.37*

15.60 ± 4.34*#

27.89 ± 4.58**#&&

22.11 ± 2.76*&

 

4.46 ± 1.57

7.68 ± 1.85*

5.81 ± 2.08

10.79 ± 1.75**#&

7.78 ± 1.64*

  1. The proportions of CD45+ inflammatory cells in all cells were compared. And then the proportions of different subpopulations in CD45+inflammatory cells (upper sub-row) and in all cells (lower sub-row) were compared. Th helper T cells, CTL cytotoxic T lymphocyte, DC dendritic cells, NK natural killer cells, NKT natural killer T cells, MDSC myeloid derived suppressor cells, M1 M1-polarized tumor associated macrophages, M2 M2-polarized tumor assocaited macrophages. Compared with Control group, * P < 0.05, ** P < 0.01; Compared with Chemo.group, # P < 0.05, ## P <0.01; Compared with Chemo. + ASP group, & P < 0.05,&& P < 0.01; Compared with Chemo. + LIP, @ P < 0.05, @@ P < 0.01; ANOVA analysis, SNK-q test
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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