Fig. 5
From: MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression
Effects of miR-23b transfection on ovarian carcinoma cell genotype in vitro. a The predicted seed region in the 3′ UTR of CCNG1 revealed that CCNG1 was direct target of miR-23b, as predicted by microRNA.org; b dual-luciferase reporter assay indicated that miR-23b significantly decreased the relative luciferase activity of the wild-type CCNG1 3′ UTR as compared with the mutant CCNG1 3′ UTR, indicating that miR-23b may directly bind to the 3′ UTR of CCNG1. c & d MiR-23b overexpression reduced CCNG1, uPA, P70S6K, Bcl-xL, survivin and MMP9 mRNA or protein expression. * p < 0.05