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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy

Fig. 4

UHRF1 inhibited prostate cancer cell apoptosis. Cells were transfected with siUHRF1-535, siUHRF1-1453, siNC, pcDNA3.1(+) or pcDNA3.1(+)-UHRF1 plasmid for 48 h, and then subjected to cell apoptosis (stained with PI and FITC-Annexin V). Knockdown of UHRF1 caused an increase in early and late apoptotic cells and a decrease in living cells in LNCaP (a, b), 22RV1 (c, d) and PC-3 (e, f). Overexpression of UHRF1 decreased the fraction of apoptotic cells in LNCaP cells (g, h). Each experiment was performed in triplicate

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