Fig. 5

PA28α knockdown significantly inhibits tumor growth through its effects on cell proliferation but not on angiogenesis and apoptosis in vivo. a The tumor volumes of HSC3 cells with the transfection of chemically modified (both 2’ OMe and 3’ Chol) siRNA-PA28α, were remarkably decreased, comparing to the siRNA-Control groups in BALB-C nude mice after 24 days (mean ± SEM, n = 6). b IOD of PCNA-positive tumor cells of siRNA-PA28α group was significantly lower than the siRNA-Control group. c No significant difference of CD34 staining between in siRNA-PA28α group and in siRNA-Control group. d No significant difference of TUNEL staining between in siRNA-PA28α group and in siRNA-Control group. Data are reported as means ± SEM for three independantly experiments. (ANOVA or T test,, * p < 0.05, ** p < 0.01, *** p < 0.001)