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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27

Fig. 8

Partial recovery of clonogenic potential in KDM5B-depleted HCC cells by inhibition of p15 and p27 induction. a Western blot analyses of KDM5B, p15 and p27 protein expression in Hep-3B and Focus cells treated with si-NC, si-2531, co-transfection of si-2531 and si-p15 and co-transfection of si-2531 and si-p27. b and c The restoration of clone formation in KDM5B-depleted Hep-3B and Focus cells by abolishment of p15 and p27 induction. *, P < 0.05 and **, P < 0.01, respectively

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