Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27

Table 1 Correlation between KDM5B expression and clinicopathological features in HCC

Clinicopathological features	n	KDM5B
Clinicopathological features	n	High expression (≥Median)	Low expression (<Median)	P-value
Gender
Male	65	34	31	0.6753
Female	35	16	19
Age (years)
≥ 50	60	32	28	0.5406
< 50	40	18	22
Tumor size (cm)
≥ 5	55	36	19	0.0012**
< 5	45	14	31
Tumor number
Solitary	62	33	29	0.5368
Multiple	38	17	21
HBsAg
Positive	76	40	36	0.4829
Negative	24	10	14
HCV
Positive	11	8	3	0.1997
Negative	89	42	47
Cirrhosis
Positive	82	43	39	0.4356
Negative	18	7	11
ALT (U/L)
≥ 45	46	26	20	0.3158
< 45	54	24	30
AFP (ng/ml)
≥ 20	57	31	26	0.4193
< 20	43	19	24
TNM stage
I + II	56	21	35	0.0085**
III + IV	44	29	15
Edmondson grade
I + II	59	23	36	0.0142*
III + IV	41	27	14

ISSN: 1756-9966