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Table 1 Correlation between KDM5B expression and clinicopathological features in HCC

From: Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27

Clinicopathological features n KDM5B
High expression
(≥Median)
Low expression
(<Median)
P-value
Gender     
 Male 65 34 31 0.6753
 Female 35 16 19  
Age (years)     
  ≥ 50 60 32 28 0.5406
  < 50 40 18 22  
Tumor size (cm)     
  ≥ 5 55 36 19 0.0012**
  < 5 45 14 31  
Tumor number     
 Solitary 62 33 29 0.5368
 Multiple 38 17 21  
HBsAg     
 Positive 76 40 36 0.4829
 Negative 24 10 14  
HCV     
 Positive 11 8 3 0.1997
 Negative 89 42 47  
Cirrhosis     
 Positive 82 43 39 0.4356
 Negative 18 7 11  
ALT (U/L)     
  ≥ 45 46 26 20 0.3158
  < 45 54 24 30  
AFP (ng/ml)     
  ≥ 20 57 31 26 0.4193
  < 20 43 19 24  
TNM stage     
 I + II 56 21 35 0.0085**
 III + IV 44 29 15  
Edmondson grade     
 I + II 59 23 36 0.0142*
 III + IV 41 27 14  
  1. The median expression level of KDM5B was used as the cut off
  2. *P < 0.05
  3. **P < 0.01 between the two groups