Fig. 4
From: Anti-tumor effects of Atractylenolide I on bladder cancer cells
ATR-1 induces apoptosis mainly through the mitochondrial pathway. a Western blot analysis of apoptosis-related proteins. b ATR-1 treatment can lead to activation of Bax (upper) and release of cytochrome-c (cyto c) and Smac/Diablo into cytosol (lower). c Silencing of Bax by specific siRNA can inhibit the activation of caspase-3. d Down-regulation of Bax significantly attenuates ATR-1-induced apoptosis. Data represent mean ± S.D. (n =3).*p < 0.05, **p < 0.01