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Table 2 Univariate and multivariate Cox proportional regression analysis of factors associated with recurrence

From: CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma

Variables

Univariate analysis

Multivariate analysis

HR (95 % CI)

P

HR (95 % CI)

P

Age (> 50yvs. ≤ 50y)

0.90 (0.55–1.48)

0.673

N.A.

N.A.

Sex (male vs. female)

1.01 (0.48–2.10)

0.990

N.A.

N.A.

HBsAg (Positive vs. Negative)

0.77 (0.33–1.77)

0.536

N.A.

N.A.

Child-Pugh score (A vs. B)

1.12 (0.27–4.55)

0.879

N.A.

N.A.

Liver cirrhosis (Yes vs. No)

0.99 (0.45–2.16)

0.977

N.A.

N.A.

AFP (> 400 ng/ml vs. ≤ 400 ng/ml)

1.73 (1.06–2.81)

0.027

1.30 (0.78–2.16)

0.309

Tumor number (Multiple vs. Single)

1.77 (1.04–3.00)

0.022

1.42 (0.82–2.48)

0.214

Tumor size (> 5 cm vs. ≤ 5 cm)

1.35 (0.79–2.31)

0.273

N.A.

N.A.

Vascular invasion (Yes vs. No)

2.16 (1.34–3.48)

0.002

1.14 (0.68–1.93)

0.621

Satellite lesion (Yes vs.No)

2.92 (1.66–5.16)

0.001

1.96 (1.06–3.63)

0.032

Tumor encapsulation (Yes vs. No)

2.26 (1.40–3.63)

0.001

1.64 (0.99–2.71)

0.054

Edmondson stage (III-IV vs. I-II)

2.15 (1.31–3.52)

0.003

1.75 (1.05–2.93)

0.032

CD146 (High vs. LOW)

3.64 (2.20–6.03)

<0.001

2.49 (2.43–4.00)

0.001

  1. Abbreviations: HBsAg Hepatitis B surface antigen, AFP α-fetoprotein