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Table 2 Univariate and multivariate Cox proportional regression analysis of factors associated with recurrence

From: CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma

Variables Univariate analysis Multivariate analysis
HR (95 % CI) P HR (95 % CI) P
Age (> 50yvs. ≤ 50y) 0.90 (0.55–1.48) 0.673 N.A. N.A.
Sex (male vs. female) 1.01 (0.48–2.10) 0.990 N.A. N.A.
HBsAg (Positive vs. Negative) 0.77 (0.33–1.77) 0.536 N.A. N.A.
Child-Pugh score (A vs. B) 1.12 (0.27–4.55) 0.879 N.A. N.A.
Liver cirrhosis (Yes vs. No) 0.99 (0.45–2.16) 0.977 N.A. N.A.
AFP (> 400 ng/ml vs. ≤ 400 ng/ml) 1.73 (1.06–2.81) 0.027 1.30 (0.78–2.16) 0.309
Tumor number (Multiple vs. Single) 1.77 (1.04–3.00) 0.022 1.42 (0.82–2.48) 0.214
Tumor size (> 5 cm vs. ≤ 5 cm) 1.35 (0.79–2.31) 0.273 N.A. N.A.
Vascular invasion (Yes vs. No) 2.16 (1.34–3.48) 0.002 1.14 (0.68–1.93) 0.621
Satellite lesion (Yes vs.No) 2.92 (1.66–5.16) 0.001 1.96 (1.06–3.63) 0.032
Tumor encapsulation (Yes vs. No) 2.26 (1.40–3.63) 0.001 1.64 (0.99–2.71) 0.054
Edmondson stage (III-IV vs. I-II) 2.15 (1.31–3.52) 0.003 1.75 (1.05–2.93) 0.032
CD146 (High vs. LOW) 3.64 (2.20–6.03) <0.001 2.49 (2.43–4.00) 0.001
  1. Abbreviations: HBsAg Hepatitis B surface antigen, AFP α-fetoprotein