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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity

Fig. 2

Representation of molecular mechanisms through which wtp53 (green) and mutp53 (red) impact on Drosha activity. Upon DNA damage, the complex p53/p68 binds the microprocessor complex fostering the maturation of a subset of pri-miRNAs to pre-miRNAs. In a cellular context in which mutp53 is expressed, the last binds p68 and p72, the Microprocessor complex is dissociated and the maturation of a subset of pri-miRNAs to pre-miRNAs is impaired

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