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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathway

Fig. 2

SOX2 knockdown by siRNA inhibited the growth capacity of Ewing’s sarcoma cells. a, and b The mRNA and protein expression levels of SOX2 were significantly repressed by the transfection of SOX2 siRNA in both A673 and RD-ES cells. c The cell viabilities were inhibited in both cell lines after SOX2 knockdown according to the MTT assay. d SOX2 inhibition resulted in a decreased colony formation capacity in both A673 and RD-ES cell lines. Representative pictures were displayed and the colonies per area were shown as data in bars. All data are presented as means ± S.D. *P < 0.01, **P < 0.001

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