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Table 2 Metabolic analysis (AK4 overexpression vs control)

From: Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

Metabolite KEGG ID Ratio p-value
Kynurenine C00328,C01718 6.73 0.001
Gln C00064,C00303,C00819 3.06 0.004
Glycerophosphocholine C00670 2.76 0.003
Thiamine diphosphate C00068 2.68 0.001
Glucose 1-phosphate C00103 2.63 0
Terephthalic acid C06337 2.55 0
PRPP C00119 2.45 0.016
N-Acetylglutamic acid C00624 2.42 0.004
Asn C00152,C01905,C16438 2.37 0
Pelargonic acid C01601 2.31 0.017
Glycerol C00116 2.24 0.003
Ser C00065,C00716,C00740 2.13 0
XA0033 No ID 2.04 0.024
Lauric acid C02679 2.02 0.007
Phosphocreatine C02305 2 0.01
dGTP C00286 2 0.008
Phosphorylcholine C00588 1.91 0
dCTP C00458 1.88 0.005
2-Hydroxyglutaric acid C02630,C01087,C03196 1.87 0.011
N-Acetylputrescine C02714 1.87 0
Glycerol 3-phosphate C00093 1.87 0.018
2-Aminobutyric acid C02261,C02356 1.87 0.004
Isovalerylcarnitine No ID 1.87 0.001
myo-Inositol 2-phosphate No ID 1.82 0.001
dATP C00131 1.75 0.003
Ornithine C00077,C00515,C01602 1.7 0.003
dADP C00206 1.67 0.021
3-Hydroxy-3-methylglutaric acid C03761 1.64 0.001
Putrescine C00134 1.62 0.021
Arg C00062,C00792 1.56 0.009
CTP C00063 1.55 0.034
Rhein C10401 1.54 0.023
Ala C00041,C00133,C01401 1.52 0.015
Thr C00188,C00820 1.48 0.003
ADP C00008 1.47 0.032
UDP-glucose C00029 1.46 0.017
UDP-galactose C00052
Carnosine C00386 1.46 0.029
Lys C00047,C00739,C16440 1.44 0.002
UDP-N-acetylglucosamine C00043 1.4 0.013
ADP-glucose C00498 1.4 0.003
GDP-fucose C00325
O-Acetylcarnitine C02571 1.4 0.007
GABA C00334 1.39 0.001
Thiamine C00378 1.39 0.019
His C00135,C00768,C06419 1.38 0.003
1-Methylnicotinamide C02918 1.38 0.002
Citrulline C00327 1.36 0.012
dTDP-glucose C00842 1.35 0.008
Val C00183,C06417,C16436 1.35 0.003
Leu C00123,C01570,C16439 1.35 0.003
Gly C00037 1.33 0.005
Ile C00407,C06418,C16434 1.32 0.001
N8-Acetylspermidine C01029 1.29 0.031
Creatinine C00791 1.29 0.003
Pantothenic acid C00864 1.28 0.009
Hydroxyproline C01157 1.27 0.035
Glutathione (GSH) C00051 1.26 0.001
Phe C00079,C02057,C02265 1.26 0.007
Met C00073,C00855,C01733 1.25 0.007
Homoserinelactone No ID 1.24 0.005
Glu C00025,C00217,C00302 1.24 0.016
Pyridoxine C00314 1.24 0.025
Trp C00078,C00525,C00806 1.22 0.017
Gluconic acid C00257 1.22 0.037
N-Formylmethionine C03145 1.21 0.034
Butyrylcarnitine C02862 0.78 0.008
Succinic acid C00042 0.76 0.013
Hypotaurine C00519 0.74 0.022
Creatine C00300 0.66 0.001
Choline C00114 0.65 0.013
Ribulose 5-phosphate C00199,C01101 0.6 0.023
XA0012 No ID 0.6 0.008
Asp C00049,C00402,C16433 0.54 0.003
dTMP C00364 0.52 0.03
XC0016 No ID 0.51 0.001
Thiamine phosphate C01081 0.48 0.038
Malic acid C00149,C00497,C00711 0.47 0.006
β-Ala C00099 0.44 0.004
Fumaric acid C00122 0.44 0.006
XC0061 No ID 0.43 0.017
3'-Dephospho CoA C00882 0.42 0.034
XA0002 No ID 0.39 0.027
CMP C00055 0.38 0.019
UMP C00105 0.38 0.031
NADP+ C00006 0.36 0.001