Table 2 Metabolic analysis (AK4 overexpression vs control)

Kynurenine

C00328,C01718

6.73

0.001

Gln

C00064,C00303,C00819

3.06

0.004

Glycerophosphocholine

C00670

2.76

0.003

Thiamine diphosphate

C00068

2.68

0.001

Glucose 1-phosphate

C00103

2.63

0

Terephthalic acid

C06337

2.55

0

PRPP

C00119

2.45

0.016

N-Acetylglutamic acid

C00624

2.42

0.004

Asn

C00152,C01905,C16438

2.37

0

Pelargonic acid

C01601

2.31

0.017

Glycerol

C00116

2.24

0.003

Ser

C00065,C00716,C00740

2.13

0

XA0033

No ID

2.04

0.024

Lauric acid

C02679

2.02

0.007

Phosphocreatine

C02305

2

0.01

dGTP

C00286

2

0.008

Phosphorylcholine

C00588

1.91

0

dCTP

C00458

1.88

0.005

2-Hydroxyglutaric acid

C02630,C01087,C03196

1.87

0.011

N-Acetylputrescine

C02714

1.87

0

Glycerol 3-phosphate

C00093

1.87

0.018

2-Aminobutyric acid

C02261,C02356

1.87

0.004

Isovalerylcarnitine

No ID

1.87

0.001

myo-Inositol 2-phosphate

No ID

1.82

0.001

dATP

C00131

1.75

0.003

Ornithine

C00077,C00515,C01602

1.7

0.003

dADP

C00206

1.67

0.021

3-Hydroxy-3-methylglutaric acid

C03761

1.64

0.001

Putrescine

C00134

1.62

0.021

Arg

C00062,C00792

1.56

0.009

CTP

C00063

1.55

0.034

Rhein

C10401

1.54

0.023

Ala

C00041,C00133,C01401

1.52

0.015

Thr

C00188,C00820

1.48

0.003

ADP

C00008

1.47

0.032

UDP-glucose

C00029

1.46

0.017

UDP-galactose

C00052

Carnosine

C00386

1.46

0.029

Lys

C00047,C00739,C16440

1.44

0.002

UDP-N-acetylglucosamine

C00043

1.4

0.013

ADP-glucose

C00498

1.4

0.003

GDP-fucose

C00325

O-Acetylcarnitine

C02571

1.4

0.007

GABA

C00334

1.39

0.001

Thiamine

C00378

1.39

0.019

His

C00135,C00768,C06419

1.38

0.003

1-Methylnicotinamide

C02918

1.38

0.002

Citrulline

C00327

1.36

0.012

dTDP-glucose

C00842

1.35

0.008

Val

C00183,C06417,C16436

1.35

0.003

Leu

C00123,C01570,C16439

1.35

0.003

Gly

C00037

1.33

0.005

Ile

C00407,C06418,C16434

1.32

0.001

N8-Acetylspermidine

C01029

1.29

0.031

Creatinine

C00791

1.29

0.003

Pantothenic acid

C00864

1.28

0.009

Hydroxyproline

C01157

1.27

0.035

Glutathione (GSH)

C00051

1.26

0.001

Phe

C00079,C02057,C02265

1.26

0.007

Met

C00073,C00855,C01733

1.25

0.007

Homoserinelactone

No ID

1.24

0.005

Glu

C00025,C00217,C00302

1.24

0.016

Pyridoxine

C00314

1.24

0.025

Trp

C00078,C00525,C00806

1.22

0.017

Gluconic acid

C00257

1.22

0.037

N-Formylmethionine

C03145

1.21

0.034

Butyrylcarnitine

C02862

0.78

0.008

Succinic acid

C00042

0.76

0.013

Hypotaurine

C00519

0.74

0.022

Creatine

C00300

0.66

0.001

Choline

C00114

0.65

0.013

Ribulose 5-phosphate

C00199,C01101

0.6

0.023

XA0012

No ID

0.6

0.008

Asp

C00049,C00402,C16433

0.54

0.003

dTMP

C00364

0.52

0.03

XC0016

No ID

0.51

0.001

Thiamine phosphate

C01081

0.48

0.038

Malic acid

C00149,C00497,C00711

0.47

0.006

β-Ala

C00099

0.44

0.004

Fumaric acid

C00122

0.44

0.006

XC0061

No ID

0.43

0.017

3'-Dephospho CoA

C00882

0.42

0.034

XA0002

No ID

0.39

0.027

CMP

C00055

0.38

0.019

UMP

C00105

0.38

0.031

NADP+

C00006

0.36

0.001