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Table 2 PC aberrant markers expression at diagnosis and during MRD monitoring by flow cytometry assessment

From: Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study

  Diagnosis Follow-up Follow-up
PC surface aberrant markers (SAM) SAM expression (% of patients) MRD-negative by cy-Ig light chains ratio on SAM percentage above the normal threshold 6, 7 (Putative surface MRD-positive) (% of samples) MRD-positive by cy-Ig light chains ratio on SAM percentage below the normal threshold 6, 7 (Putative surface MRD-negative) (% of samples)
CD19neg 98 % CD19neg ≥30 % 2.5 % CD19neg <30 % 26 %
CD45weak/neg 63 % CD45weak/neg ≥6 % 38 % CD45weak/neg <6 % 39 %
CD56pos 74 % CD56pos ≥15 % 15 % CD56pos <15 % 27 %
CD117pos 41 % CD117pos ≥1 % 0 % CD117pos <1 % na
CD33pos 26 % CD33pos ≥6 % 60 % CD33pos <6 % 0 %
  1. PC plasma cells, SAM surface aberrant marker, SAM% calculated within the CD38pos PC population, MRD minimal residual disease, cy-Ig cytoplasmic immunoglobulin, na not applicable
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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