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Table 2 PC aberrant markers expression at diagnosis and during MRD monitoring by flow cytometry assessment

From: Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study

 

Diagnosis

Follow-up

Follow-up

PC surface aberrant markers (SAM)

SAM expression (% of patients)

MRD-negative by cy-Ig light chains ratio on SAM percentage above the normal threshold 6, 7 (Putative surface MRD-positive) (% of samples)

MRD-positive by cy-Ig light chains ratio on SAM percentage below the normal threshold 6, 7 (Putative surface MRD-negative) (% of samples)

CD19neg

98 %

CD19neg ≥30 %

2.5 %

CD19neg <30 %

26 %

CD45weak/neg

63 %

CD45weak/neg ≥6 %

38 %

CD45weak/neg <6 %

39 %

CD56pos

74 %

CD56pos ≥15 %

15 %

CD56pos <15 %

27 %

CD117pos

41 %

CD117pos ≥1 %

0 %

CD117pos <1 %

na

CD33pos

26 %

CD33pos ≥6 %

60 %

CD33pos <6 %

0 %

  1. PC plasma cells, SAM surface aberrant marker, SAM% calculated within the CD38pos PC population, MRD minimal residual disease, cy-Ig cytoplasmic immunoglobulin, na not applicable