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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model

Fig. 5

In vivo effects of peptide R treatment on iNOS expression by macrophage/microglia. a CLSM analyses of the double staining with CD11b (red) and iNOS (green) antibodies performed on brain sections of vehicle-treated (CTRL), or peptide R- or Plerixafor-treated mice. Images were taken both in the tumor core and at the tumor edge, as indicated. Asterisks (*) indicate the tumor-free parenchyma. Scale bars, 50 μm. b Mean intensity of CD11b and iNOS fluorescence (upper panels) and percentage of colocalized area (lower panel) in the tumor core were analysed by Image J software and reported as mean values ± SD (n = 4 images for each treatment group). *P = 0.0226 and **P = 0.0057 (asterisks shown in figure), one-way ANOVA. P = 0.0448 and P = 0.0084 (peptide R versus CTRL and Plerixafor), unpaired two-tailed Student t-test

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