Drug combination | Combination ratio | (Dm)IC50 (μM) | CI values at inhibition of | DRI values at inhibition of | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Drug 1 | Drug 2 | COMBINED | 50Â % | 75Â % | 90Â % | 95Â % | 97Â % | 50Â % | 75Â % | 90Â % | 95Â % | 97Â % | ||
(1) | (1) | (1) | (1) | (1) | ||||||||||
(2) | (2) | (2) | (2) | (2) | ||||||||||
Colchicine + MBIC | 1:1 | 3.01 ± 0.7 | 0.21 ± 0.02 | 0.076 ± 0.03 | 0.10 | 0.06 | 0.04 | 0.02 | 0.02 | 165.4 | 356.8 | 769.7 | 1298.3 | 1883.3 |
9.9 | 15.8 | 25.4 | 35.1 | 44.1 | ||||||||||
Nocodazole + MBIC | 1:1 | 3.08 ± 0.5 | 0.21 ± 0.02 | 0.087 ± 0.02 | 0.27 | 0.20 | 0.14 | 0.11 | 0.10 | 20.6 | 31.1 | 46.7 | 61.7 | 75.2 |
4.3 | 5.8 | 7.9 | 9.7 | 11.2 | ||||||||||
Paclitaxel + MBIC | 1:1 | 1.02 ± 0.6 | 0.21 ± 0.02 | 0.104 ± 0.06 | 0.35 | 0.28 | 0.23 | 0.20 | 0.18 | 15.3 | 18.4 | 22.1 | 25.0 | 27.3 |
3.4 | 4.2 | 5.1 | 5.9 | 6.5 | ||||||||||
Doxorubicin + MBIC | 1:1 | 0.46 ± 0.7 | 0.21 ± 0.02 | 0.092 ± 0.03 | 0.30 | 0.22 | 0.17 | 0.14 | 0.12 | 12.5 | 17.7 | 25.0 | 31.6 | 37.3 |
4.4 | 5.7 | 7.5 | 9.1 | 10.3 |