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Table 2 Prognostic impact of ID1/ID3/IGJ expression signature in the context of other clinical and molecular parameters

From: High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia

  Univariate model Multivariate model pre-treatment variables Multivariate model pre-treatment variables and MRD
Parameter p Value OR (95 % CI) p Value OR (95 % CI) p Value OR (95 % CI)
EVENT
 Gene profile 0.029 6.57 (1.217–35.529) 0.029 6.57 (1.217–35.529) 0.029 6.57 (1.217–35.529)
 Age >30 0.052 3.48 (0.990–12.242) 0.120 2.86 (0.759–10.779) 0.405 1.89 (0.420–8.553)
 WBCC >30.000/ul 0.090 4.09 (0.803–20.870) 0.315 2.10 (0.494–8.932) 0.152 3.55 (0.628–20.118)
 MRD 0.077 4.05 (0.859–19.085)    0.114 3.29 (0.752–14.452)
COMPLETE REMISSION
 Gene profile 0.016 6.48 (1.413–29.713) 0.016 6.48 (1.413–29.713)   
 Sex 0.092 0.14 (0.016–1.366) 0.313 0.43 (0.089–2.170)   
EVENT FREE SURVIVAL
 Gene profile 0.004 3.58 (1.493–8.597) 0.004 3.58 (1.493–8.597) 0.017 3.08 (1.223–7.759)
 Age >30 0.056 2.40 (0.979–5.922) 0.139 2.00 (0.799–5.027) 0.533 1.37 (0.504–3.760)
 MRD <0.001 1.00 (1.001–1.004)    <0.001 1.002 (1.001–1.003)
OVERALL SURVIVAL
 Gene profile 0.008 3.97 (1.439–111.000) 0.029 3.21 (1.127–9.176) 0.122 2.41 (0.789–7.408)
 Platelets count 0.002 1.00 (1.000–1.000) 0.015 1.00 (1.000–1.000) 0.002 1.00 (1.000–1.000)
 Age >30 0.060 4.08 (0.944–17.655) 0.025 4.32 (1.204–15.550) 0.060 4.08 (0.944–17.655)
 t(9;22) 0.076 0.08 (0.005–1.298) 0.327 0.34 (0.040–2.927) 0.076 0.08 (0.005–1.298)
 MRD <0.001 1.00 (1.002–1.005)    <0.001 1.00 (1.002–1.008)