Table 2 Prognostic impact of ID1/ID3/IGJ expression signature in the context of other clinical and molecular parameters
| Â | Univariate model | Multivariate model pre-treatment variables | Multivariate model pre-treatment variables and MRD | |||
|---|---|---|---|---|---|---|
Parameter | p Value | OR (95 % CI) | p Value | OR (95 % CI) | p Value | OR (95 % CI) |
EVENT | ||||||
 Gene profile | 0.029 | 6.57 (1.217–35.529) | 0.029 | 6.57 (1.217–35.529) | 0.029 | 6.57 (1.217–35.529) |
 Age >30 | 0.052 | 3.48 (0.990–12.242) | 0.120 | 2.86 (0.759–10.779) | 0.405 | 1.89 (0.420–8.553) |
 WBCC >30.000/ul | 0.090 | 4.09 (0.803–20.870) | 0.315 | 2.10 (0.494–8.932) | 0.152 | 3.55 (0.628–20.118) |
 MRD | 0.077 | 4.05 (0.859–19.085) |  |  | 0.114 | 3.29 (0.752–14.452) |
COMPLETE REMISSION | ||||||
 Gene profile | 0.016 | 6.48 (1.413–29.713) | 0.016 | 6.48 (1.413–29.713) |  |  |
 Sex | 0.092 | 0.14 (0.016–1.366) | 0.313 | 0.43 (0.089–2.170) |  |  |
EVENT FREE SURVIVAL | ||||||
 Gene profile | 0.004 | 3.58 (1.493–8.597) | 0.004 | 3.58 (1.493–8.597) | 0.017 | 3.08 (1.223–7.759) |
 Age >30 | 0.056 | 2.40 (0.979–5.922) | 0.139 | 2.00 (0.799–5.027) | 0.533 | 1.37 (0.504–3.760) |
 MRD | <0.001 | 1.00 (1.001–1.004) |  |  | <0.001 | 1.002 (1.001–1.003) |
OVERALL SURVIVAL | ||||||
 Gene profile | 0.008 | 3.97 (1.439–111.000) | 0.029 | 3.21 (1.127–9.176) | 0.122 | 2.41 (0.789–7.408) |
 Platelets count | 0.002 | 1.00 (1.000–1.000) | 0.015 | 1.00 (1.000–1.000) | 0.002 | 1.00 (1.000–1.000) |
 Age >30 | 0.060 | 4.08 (0.944–17.655) | 0.025 | 4.32 (1.204–15.550) | 0.060 | 4.08 (0.944–17.655) |
 t(9;22) | 0.076 | 0.08 (0.005–1.298) | 0.327 | 0.34 (0.040–2.927) | 0.076 | 0.08 (0.005–1.298) |
 MRD | <0.001 | 1.00 (1.002–1.005) |  |  | <0.001 | 1.00 (1.002–1.008) |