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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

Fig. 1

FISH analysis of TOP1 (red) and CEN-20 (green) aberrations in parental and SN-38-resistant cells. Shown are representative cell metaphase FISH images of parental (HCT116-Wt, HT29-Wt and LoVo-Wt) and SN-38 resistant (HCT116-SN38, HT29-SN38 and LoVo-SN38) cell lines. HCT116-SN38A and –B designate the two subpopulations observed in the HCT116-SN38 cell line. See text and Table 1 for details. Note: Due to the existence of two chromatids in each metaphase chromosome, the observed number of gene signals is double that of what is observed in an interphase nucleus

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