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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

Fig. 4

Enzymatic activity of Top1 in nuclear extract from parental and SN-38 resistant cells. a Top1 activity at different dilutions of nuclear extract in the absence of SN-38. b Top1 activity measured in the presence of increasing concentrations of SN-38. DMSO is the vehicle control without SN-38. Mean values ± standard deviations are plotted

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