Fig. 5

Drug sensitivity assays for parental and SN-38-resistant cells against two non-camptothecin Top1-targeting drugs (NSC 725776/LMP776 and NSC 743400/LMP400) in clinical trial and two clinical Top2-targeting drugs (epirubicin and etoposide). Green solid lines are the parental cells and blue dotted lines are the SN-38 resistant cells. Cells were exposed to drug for 48 h and cell viability determined using the MTT assay. Shown are representative results