From: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations
Cell line
Mutations detecteda
Locationb
HCT116-SN38
c.1336C > T (R364K), c.2395G > A (G717R)
Exon 12, exon 20
HT29-SN38
None
-
LoVo-SN38