Skip to main content

Table 2 Mutations in TOP1

From: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

Cell line

Mutations detecteda

Locationb

HCT116-SN38

c.1336C > T (R364K), c.2395G > A (G717R)

Exon 12, exon 20

HT29-SN38

None

-

LoVo-SN38

None

-

  1. Both mutations are heterozygous
  2. aComparing sequences of resistant and parental cell lines
  3. bInformation from the NCBI (www.ncbi.nlm.nih.gov)