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Table 2 Mutations in TOP1

From: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

Cell line Mutations detecteda Locationb
HCT116-SN38 c.1336C > T (R364K), c.2395G > A (G717R) Exon 12, exon 20
HT29-SN38 None -
LoVo-SN38 None -
  1. Both mutations are heterozygous
  2. aComparing sequences of resistant and parental cell lines
  3. bInformation from the NCBI (www.ncbi.nlm.nih.gov)