Skip to main content

Table 1 Relationship between SHH expression and clinicopathologic characteristics in GC patients

From: Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway

Characteristic N SHH Expression   
Low(n = 69) High(n = 48) Χ 2 Value P value
Gender      
 Male 71 41 (59.42 %) 30 (62.50 %) 0.113 0.444
 Female 46 28 (40.58 %) 18 (37.50 %)   
Age (years)      
 <60 y 74 43 (62.38 %) 31 (64.58 %) 0.062 0.479
  ≥ 60 y 43 26 (37.62 %) 17 (35.42 %)   
Location      
 Proximal 14 10 (14.49 %) 4 (8.33 %) 1.973 0.578
 Middle 18 10 (14.49 %) 8 (16.67 %)   
 Distal 59 32 (46.38 %) 27 (56.25 %)   
 More than 2 26 17 (24.64 %) 9 (18.75 %)   
Tumor size      
 <5 cm 67 37 (53.62 %) 30 (62.50 %) 0.911 0.223
  ≥ 5 cm 50 32 (46.38 %) 18 (37.50 %)   
Histologic type      
 Adenocarcinoma 98 59 (85.51 %) 39 (81.25 %) 0.377 0.357
 Others 19 10 (14.49 %) 9 (18.75 %)   
Bormann classification      
 1 6 4 (5.80 %) 2 (4.17 %) 0.476 0.924
 2 24 15 (21.74 %) 9 (18.75 %)   
 3 69 39 (56.52 %) 30 (62.50 %)   
 4 18 11 (15.94 %) 7 (14.58 %)   
Differentiation grade      
 Well 26 19 (27.54 %) 7 (14.58 %) 2.924 0.232
 Moderately 66 48 (69.56 %) 40 (83.33 %)   
 Poorly 25 2 (2.90 %) 1 (2.08 %)   
pT staging      
 T1–2 28 10 (14.49 %) 18 (37.50 %) 8.231 0.004
 T3–4 89 59 (85.51 %) 30 (62.50 %)   
pN staging      
 N0 20 7 (10.14 %) 13 (27.08 %) 5.731 0.017
 N1-3 97 62 (89.86 %) 35 (72.92 %)   
pM staging      
 M0 104 66 (95.65 %) 38 (79.17 %) 7.789 0.006
 M1 13 3 (4.35 %) 10 (20.83 %)   
pTNM staging      
 I–II 36 31 (44.93 %) 5 (10.42 %) 15.827 <0.001
 III–IV 81 38 (55.07 %) 43 (89.58 %)