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Table 2 Univariate and multivariate analyses of clinicopathological factors for overall survival in GC patients

From: Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway

Variables Univariate analysis Multivariate analysis
  HR 95 % CI P value HR 95 % CI P value
   Lower Upper    Lower Upper  
Gender 0.580 0.360 0.934 0.025 0.576 0.371 0.895 0.014
Age 1.682 1.071 2.641 0.024 1.634 1.066 2.505 0.024
Tumor location 0.972 0.736 1.285 0.844     
Tumor size 1.045 0.636 1.717 0.862     
Histologic type 0.890 0.686 1.155 0.380     
Bormann classification 1.089 0.811 1.461 0.571     
Differentiation grade 0.623 0.389 0.997 0.049 0.602 0.377 0.962 0.034
pT staging 0.742 0.274 2.007 0.557     
pN staging 1.652 1.221 2.234 0.001 1.682 1.365 2.072 <0.001
pM staging 3.017 1.536 5.926 0.001 3.003 1.582 5.701 0.001
pTNM staging 1.272 0.488 3.315 0.622     
SHH expression 1.776 1.119 2.820 0.015 1.734 1.109 2.713 0.016