Fig. 4
From: miR-539 inhibits prostate cancer progression by directly targeting SPAG5
SPAG5 plays a critical role in PCa growth and metastasis in vivo. a, b, SPAG5 knockdown in PCa cells significantly inhibits tumor growth in a mouse xenograft model; c, d, Tumor weights of corresponding mouse xenograft models; e-g, SPAG5 expression analysis was conducted at protein level by immunohistochemical analysis and western blot. h, SPAG5 played an important role in PCa metastasis in vivo. Ectopic expression of miR-539 can mimic the effects induced by SPAG5 knockdown. All * indicated P value less than 0.05