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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: EphA1 activation promotes the homing of endothelial progenitor cells to hepatocellular carcinoma for tumor neovascularization through the SDF-1/CXCR4 signaling pathway

Fig. 1

EphA1 regulates EPC proangiogenic potency in a paracrine fashion in vitro. a A1: WB assay showing the EphA1 protein expression in HCC cells. A2: EPC incorporation into HUVECs, EPC’s uptake of DiI-ac-LDL (red) together with HUVEC tube formation (blue). A3: EPC incorporation assay analysis data (**P < 0.01). The data are expressed as the means ± SD of three independent experiments. b Boyden chamber staining of EPCs’ chemotaxis to HCC cells with different EphA1 levels, Asterisks indicate significant differences (**P < 0.01, ***P < 0.001) with respect to the corresponding control. The data are expressed as the mean ± SD of three independent experiments. c: EPC migration. d EPC tube formation. The migration and tube formation of EPCs were measured after treatment with conditioned medium from HCC cells with different EphA1 levels. The data are expressed as the mean ± SD of three independent experiments. Asterisks indicate significant differences (**P < 0.01, ***P < 0.001) with respect to the corresponding control

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