Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization

Table 2 Univariate and multivariate Cox proportional hazards regression analysis for prediction of OS

Parameter	P value	HR	95 % CI
Univariate Cox proportional hazards regression analysis
CTC ≥ 3/7.5 ml	0.037	3.383	1.079–10.608
Higher TNM staging	0.014	4.689	1.374–16.000
CA19-9 ≥ 200 U/ml	<0.001	3.216	1.674–6.192
Age ≥ 60	0.040	3.853	1.063–13.967
Multivariate Cox proportional hazards regression analysis
CTC ≥ 3/7.5 ml	0.016	4.547	1.323–15.625
Higher TNM staging	0.012	2.742	1.245–6.041
CA19-9 ≥ 200 U/ml	0.248	2.332	0.555–9.796
Age ≥ 60	0.366	1.990	0.447–8.863

Note: Cox proportional hazards models. All statistical tests were two-sided. CTCs were collected in 7.5 ml peripheral venous blood. OS, overall survival; CTC, circulating tumor cell; HR, hazard ratio; CI, confidence interval

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