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Table 2 Univariate and multivariate Cox proportional hazards regression analysis for prediction of OS

From: Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization

Parameter P value HR 95 % CI
Univariate Cox proportional hazards regression analysis
CTC ≥ 3/7.5 ml 0.037 3.383 1.079–10.608
Higher TNM staging 0.014 4.689 1.374–16.000
CA19-9 ≥ 200 U/ml <0.001 3.216 1.674–6.192
Age ≥ 60 0.040 3.853 1.063–13.967
Multivariate Cox proportional hazards regression analysis
CTC ≥ 3/7.5 ml 0.016 4.547 1.323–15.625
Higher TNM staging 0.012 2.742 1.245–6.041
CA19-9 ≥ 200 U/ml 0.248 2.332 0.555–9.796
Age ≥ 60 0.366 1.990 0.447–8.863
  1. Note: Cox proportional hazards models. All statistical tests were two-sided. CTCs were collected in 7.5 ml peripheral venous blood. OS, overall survival; CTC, circulating tumor cell; HR, hazard ratio; CI, confidence interval