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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b

Fig. 2

The expression of B55δ is increased by cDDP in HepG2 cells. a PP2A activity and (e) B55δ protein levels in HepG2 cells treated with 0, 1, 2.5, or 4 μg/ml cDDP for 12 h, or treated with 2.5 μg/ml cDDP for 0, 6, 12, or 24 h. b-d HepG2 cells were treated with or without 2.5 μg/ml cDDP for 12 h. b The mRNA levels of PP2A subunits (PPP2R1A, PPP2CA, PPP2R2A, PPP2R2D and PPP2R5C). c The protein levels of PP2A-Aα, -C, -B55α, -B55δ, and -B56γ subunits. d Immunofluorescence images of B55δ in HepG2 cells (×630 magnification; scale bar, 10 μm). Data are presented as mean ± SD of three independent assays. *P < 0.01 as compared with cDDP-untreated group (Ctrl)

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