Fig. 5
Overexpression of B55δ promotes the sensitivity of HCC xenograft tumors to cDDP. Nude mice transplanted with HepG2-pBabe or HepG2-2R2Dc cells were injected with or without 1 mg/kg body weight cDDP every other day for 3 times. a Graph depicts the tumor volume of the four groups (pBabe-Ctrl, pBabe-cDDP, 2R2Dc-Ctrl, and 2R2Dc-cDDP). b Representative images of tumors excised from nude mice. c Scatter plot shows the tumor weights for the four groups. Values shown are mean ± SD of six different samples. *P < 0.01 as compared with pBabe-Ctrl group; # P < 0.01 as compared with pBabe-cDDP group. d IHC images of sections of tumors reveal the expression of B55δ, Cyclin B1, Cyclin E1, and PCNA (×1000 magnification; scale bar, 20 μm). e WB was performed to detect B55δ, Cyclin B1, Cyclin E1, PCNA, Bcl-2, Bax, and cleaved Caspase-3 protein levels in 12 representative tumor tissues (n = 3 in each group)