Fig. 10

Wnt/β-catenin signaling is a mediator for CTNND1-induced proliferative migration, and invasion in HCC cells. a the expression of β-catenin was analyzed by Western blotting in ectopic expression β-catenin in SK-Hep-1-shCTNND1 #1 cells. b The proliferation of the SK-Hep-1-shCTNND1-β-catenin cell line and its control cells was examined by MTT assay. c indicated cells were subjected to Transwell migration (top), and Matrigel invasion assays (bottom), quantification of migrated cells through the membrane and invaded cells through Matrigel of each cell line are shown as proportions of their vector controls. d the expression of β-catenin was analyzed by Western blotting in β-catenin knocking down cells. e The proliferation of the SNU-449-CTNND1-siβ-catenin cell line and its control cells was examined by MTT assay. f indicated cells were subjected to Transwell migration (top), and Matrigel invasion assays (bottom), quantification of migrated cells through the membrane and invaded cells through Matrigel of each cell line are shown as proportions of their vector controls. ^**, P < 0.01 is based on the Student t test. All results are from three independent experiments. Error bars, SD