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Fig 4 | Journal of Experimental & Clinical Cancer Research

Fig 4

From: MicroRNA-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2

Fig 4

DEC2 was a direct target of miR-138. a The DEC2 3′UTR region containing the wild type or mutant binding site for miR-138. b The relative luciferase activity of DEC2 wild type or mutant 3'UTR in HEK293 cells following transfection with the miR-138 mimic. c Fold change of DEC2 mRNA expression and relative DEC2 protein expression in U2OS cells following transfection with the miR-138 mimic. Lane 1, miR-Ctrl; lane 2, miR-138 mimic. d Fold change of DEC2 mRNA expression and relative DEC2 protein expression in MG-63 cells following transfection with the miR-138 inhibitor. Lane 1, miR-Ctrl; lane 2, miR-138 inhibitor. * P < 0.05 and # P < 0.01 compared with the miR-Ctrl

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