TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells

Table 2 Positivity and composite scores of TET3 in ovarian cancer tissues

			Immunohistochemical composite scores
Subtypes of ovarian cancer	Overall Positivity^a	P value^b	Mean	SD	P value^c
Normal (n = 14)	12 (85.7 %)		1.21	0.90
Ca (n = 68)	52 (76.5 %)	0.724	0.72	0.72	0.0269*
EOC
Serous cancer (n = 37)	29 (78.4 %)	0.707	0.71	0.70	0.0401*
Mucinous cancer (n = 8)	8 (100 %)	0.515	1.16	0.78	0.8932
Endometrioid cancer (n = 5)	4 (80 %)	1.000	1.10	1.06	0.8182
Clear cell cancer (n = 5)	5 (100 %)	1.000	0.86	0.67	0.4345
Germ cell tumor
Dysgerminomas (n = 3)	1 (33.3 %)	0.121	0.10	0.17	0.0541
Endodermal sinus tumor (n = 1)	0
Immaure teratomas (n = 2)	1 (50.0 %)	0.350	0.40	0.56	0.2402
Granulosa cell tumor (n = 3)	2 (66.7 %)	0.456	0.40	0.35	0.1508

^aPercentage of cases with more than 5 % positive cells. ^bFisher’s Exact Test (two-tailed), compared with the positive percentage of normal tissues. ^ct-test (two-tailed), compared with the composite scores of normal cases. * P < 0.05

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