Fig. 4

Decreased blood concentrations of tumor growth factors and tumor concentrations of VEGF expression by combining GT and Q with Doc. Blood samples were collected from each mouse at sacrificing and serum separated. Eight blood samples were randomly selected from each group for this analysis. The levels of 8 growth factors in blood were simultaneously measured using a Human Growth Factor ELISA Strip II kit. Data are presented as mean ± SD (a). Eight tumor samples were randomly selected from each group for Western blot analysis of VEGF protein expression. Three representative protein images from each group were demonstrated (b). The relative concentrations of VEGF in tumor tissues are presented as mean ± SD (c). GT, green tea; Q, quercetin; Doc 5, docetaxel at 5 mg/kg iv. Columns with different letters represent significant difference between treatments (P < 0.05)